Region Industry Niche Opportunity
Charlottesville Energy Nuclear and fossil fuel power generation
Green construction
Alternative Energy
Information Technology Data management, analytics, and storage
Software development and applications
Education-based technologies
Semiconductor technology
Life Sciences Biotechnology
Health IT
Medical devices and software
Drug discovery and therapeutics
Bioinformatics
National Security Defense intelligence
Cyber security 
Information assurance
Specialty Manufacturing Components and systems
Surface engineering
Electronics
Sensors and robotics
In-vitro diagnostic substances manufacturing
Perishable prepared food manufacturing

Region Industry Niche Opportunity
Fredericksburg Energy Green technology - efficiency and conservation
Green construction and net zero buildings
Smart grid
Smart meter technology
Information Technology Cyber security
Information assurance
Software development for data analytics
Data management and analytics
Health IT
Robotics software

Data imaging and forms processing

Information security

Software development and applications

Education-based technologies

Social media technology and analytics

Advanced medical information systems

RFID logistics and management systems
National Security Secure federal telework
Human factors engineering
Defense logistics training
Forensics
Cyber security
Defense intelligence
Homeland security intelligence
Security modeling and simulation
Advanced Manufacturing Robotic surveillance and unmanned vehicle systems
Sensors and robotic systems
Pharmaceutical manufacturing
Modeling and Simulation Logistics
Advanced defense technologies
Homeland security and defense: extreme event and risk analysis, emergency management
Defense tactical systems

Region Industry Niche Opportunity
Hampton Roads Advanced Manufacturing Next-generation shipbuilding
Robotics and unmanned vehicles
Port security
Sensors and environmental monitoring
Cyber security
Aerospace Remote environmental monitoring
Support to federal research
Instrumentation and calibration services
Autonomous systems for space exploration
Life Sciences Computer-assisted drug design
Regenerative medicine
Cancer treatment and prevention
Medical devices – advanced prosthetics
Health IT
Life Sciences Computer-assisted drug design
Regenerative medicine
Cancer treatment and prevention
Medical devices - advanced prosthetics
Health IT
Logistics With respect to supply chain – the Port
Sea Level Rise Technology  Resiliency
Unmanned Systems Aviation, surface, subsurface

Region Industry Niche Opportunity

Northern Virginia 

Advanced Manufacturing Semiconductors
Nanotechnology
Aerospace Satellites
Launch vehicles
Missile defense systems
Cyber Security Cyber security
Information assurance
Homeland security and defense
Energy Green engineering and construction
Smart grid applications and analytics
Alternative energy
Information Technology Data management, analytics, and storage
Software and application development
Telecommunications and broadband
Modeling and simulation
Social media/technology
Life Sciences Biotechnology and biometrics
Bioinformatics
Health IT
Personalized medicine
Medical devices and software

Region Industry Niche Opportunity

Region 2000 

Advanced Manufacturing Integrated communications
Sensing and measurement technologies
Machine support to nuclear industry
Robotics
Nuclear materials, container design, analysis, fabrication and testing
Welding technologies
Communications Wireless RF
Remote sensor development and monitoring
Software-defined (cognitive) radio
Integration of 4th generation cell technology into radio use
Education Technology Mobile and distance learning
Energy Existing nuclear plant life extension
Nuclear fuel reprocessing
Small modular reactors
Nuclear control room simulation
Plant and grid security
Control room technologies

Region Industry Niche Opportunity
Richmond  Advanced Manufacturing Surface engineering
Robotics and automated materials handling
Chemicals
Energy Energy storage and efficiency
Smart grid applications and analytics
Smart appliances
Alternative energy
Information Technology Cyber security
Data management, analytics and storage
Software and application development
Life Sciences Biotechnology
Pharmaceuticals
Health IT
Medical devices and software

Region Industry Niche Opportunity
Roanoke/Blacksburg Advanced Engineering/Manufacturing System-based manufacturing
Advanced materials/chemicals
Nanotechnology
Energy Systems Power electronics
Smart grid technology and applications
Energy data mining, management and analytics
Smart and net-zero construction
Heavy duty vehicle conversion to hybrid
Carbon capture and storage
Information Technology/Software Applied Informatics Data management, analytics and storage
Web 2.0 and social networks
Software and application development
Utility computing, web services
Life and Medical Sciences / Devices Bioinformatics
Drug discovery and design
Personalized medicine
Remote patient monitoring and care delivery
Integration of social media and technology
Health-related wireless sensors and networks
Transportation Technology Intermodal port operation
Vehicle/driver monitoring
Smart infrastructure sensing and technology
Autonomous vehicles
Vehicle telematics

Region Industry Niche Opportunity
Shenandoah Valley Energy Renewable energy and systems, production and manufacturing
Information Technology

Cyber security

Unmanned systems and robotics
Data management and analytics
Education technology
Life Sciences and Agriculture Biotechnology, including agricultural and industrial
Drug R&D therapeutics, vaccines, diagnostics for infectious diseases (humans and animals), countermeasures to biological threats
Medical devices
Food processing

Region Industry Niche Opportunity
Southern Piedmont Advanced Manufacturing Advanced fuel cell research and manufacturing
Custom manufacturing
Robotics and unmanned systems
Nano solar cells used to make hydrogen for fuel cells
Energy-efficient coatings
Energy Plug-in hybrid electric conversion
Energy storage platforms - NaBH4/H2O2 fuel cells in autonomous vehicles and robots and ultra-capacitor technology
Vehicle performance
Energy-related mining and equipment technology
Information Technology Health IT
Data analytics
Data imaging and forms processing
Cyber security
Modeling and simulation
Life Sciences and Agriculture Micro propagation
Biopolymers

Region Industry Niche Opportunity

Southwest Virginia 

Advanced Manufacturing Defense ordinance and tactical systems
Advanced energy efficient coatings
Mine safety and productivity systems
Telecommunications and power distribution equipment
Energy Bioenergy - cellulosic ethanol
Energy-related mining and equipment technology
Biomass waste-to-energy
Clean-coal and energy projects
Coal bed methane conversion
Landfill gas utilization
Information Technology Health IT
Application development
Data analytics and storage
Life Sciences and Healthcare Telemedicine - remote patient monitoring and diagnostics and care delivery
Personalized medicine
Tobacco use for incubating vaccines
EMR data storage, mining and analytics
Purification of water
UAV / UAS UAS test range
Remote medical / pharmaceutical delivery
UAS entrepreneurship and accelerator